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Weight loss surgery helps reverse type 2 diabetes for some -study

Source: Reuters - Mon, 31 Mar 2014 12:38 GMT
Author: Reuters
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(Adds study details, background, researcher comment)

By Bill Berkrot and Ransdell Pierson

WASHINGTON, March 31 (Reuters) - Bariatric weight loss surgery on obese patients with type 2 diabetes helped many to get their blood sugar to healthy levels and to no longer require any diabetes medicines, including insulin, three years after the procedure, according to data presented at a major medical meeting on Monday.

The surgery also helped patients reduce the need for high blood pressure and cholesterol medicines and led to quality of life improvements compared with those who received medical weight-loss therapy, researchers found.

The study called Stampede, which involved 150 obese patients who had poorly controlled type 2 diabetes for at least eight years, was conducted by Cleveland Clinic researchers.

It compared two types of weight loss surgery against weight loss attained by diet and exercise along with nutrition counseling and, for some, additional diabetes medicines that can help promote weight loss, such as Victoza from Novo Nordisk . All patients were already taking at least three diabetes drugs and at least three heart medicines.

More than a third - 37.5 percent - of patients who underwent gastric bypass surgery and a quarter of those who had a sleeve gastrectomy procedure achieved blood sugar levels below the American Diabetes Association target and no longer needed diabetes medicines, researchers said. That compared with just 5 percent of patients in the medical therapy group who got their A1c blood sugar levels down to 6 percent or less. ADA recommendations call for A1c levels of 7 or less.

At three years, only 5 to 10 percent of the surgery patients were still using insulin compared with 55 percent in the medical therapy group.

"Initially we thought diabetes was a disease you could not reverse or end. We do realize now that there may be a treatment that could end diabetes for some people and that's exciting," said Dr. Sangeeta Kashyap, one of the study's lead investigators.

Results of the study were presented at the American College of Cardiology scientific meeting in Washington and published in the New England Journal of Medicine.

An estimated one third of Americans are considered obese and obesity is the leading contributor to the growing type 2 diabetes epidemic.

While bariatric surgery is a drastic measure and not without potential complications, such as infections or blood clots, for some obese patients it may be worthwhile if it can stave off the toll of advanced diabetes that can include heart and kidney disease and vascular problems that may lead to amputations or blindness.

"The fact that the surgeries can reverse the path of physiology of the disease is pretty remarkable," said Kashyap, a Cleveland Clinic endocrinologist.

Should the findings lead to a surge in weight loss surgery, it could be a boon to companies that make products used in the procedures, such as Johnson & Johnson's Ethicon unit, a study sponsor, Stryker Corp, Intuitive Surgical Inc and Covidien, among others.

Data from the study was presented in 2012 showing the effect of the surgery on diabetes after one year. The latest data answers questions of whether the effect could be lasting.

"The results were durable and they were far better than the people in the medical arm," said Kashyap. "It's effect is persistent for three years, which we think is very encouraging."

On average, gastric bypass patients lost 24 percent of their body weight and sleeve gastrectomy led to a 21 percent weight reduction, about five or six times more weight than the medical group, and more than has been demonstrated by new weight loss drugs that were not used in the study. The medical therapy group on average lost about 12 pounds each (5.4 kg), researchers said.

Gastric bypass and sleeve gastrectomy are both methods that restrict the food capacity of the stomach. Bypass also involves connecting a new gastric pouch directly into the intestine, bypassing the stomach and part of the intestines. (Reporting by Bill Berkrot and Ransdell Pierson; Editing by James Dalgleish)

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